منابع مشابه
mini spindles
We describe a new Drosophila gene, mini spindles (msps) identified in a cytological screen for mitotic mutant. Mutation in msps disrupts the structural integrity of the mitotic spindle, resulting in the formation of one or more small additional spindles in diploid cells. Nucleation of microtubules from centrosomes, metaphase alignment of chromosomes, or the focusing of spindle poles appears muc...
متن کاملThe Drosophila Microtubule-Associated Protein Mini Spindles Is Required for Cytoplasmic Microtubules in Oogenesis
The XMAP215/TOG family of proteins is a closely related set of MAPs (microtubule-associated proteins) found in animals, yeast, and plants . In yeast and animal cells, the XMAP215/TOG proteins are required for both mitosis and meiosis. Although effects of XMAP215/TOG proteins on cytoplasmic microtubules have not previously been shown in animal cells, in plants the Arabidopsis family member MOR1 ...
متن کاملMicrotubules, the ER and Exu: New associations revealed by analysis of mini spindles mutations
During Drosophila oogenesis, organized microtubule networks coordinate the localization of specific RNAs, the positioning of the oocyte nucleus, and ooplasmic streaming events. We used mutations in mini spindles (msps), a microtubule-associated protein, to disrupt microtubule function during mid- and late-oogenesis, and show that msps is required for these microtubule-based events. Since endopl...
متن کاملMini spindles, the XMAP215 homologue, suppresses pausing of interphase microtubules in Drosophila.
Drosophila Mini spindles (Msps) protein belongs to a conserved family of microtubule-associated proteins (MAPs). Intriguingly, this family of MAPs, including Xenopus XMAP215, was reported to have both microtubule stabilising and destabilising activities. While they are shown to regulate various aspects of microtubules, the role in regulating interphase microtubules in animal cells has yet to be...
متن کاملSleep Spindles
The development of EEC sleep-spindles in prematurely-born and full-term infants was studied to test an hypothesized impact of experience (longer extrauterine existence) upon innate maturational factors (EEG development). The age of otiset of sleep spindles and achievement of mature spindle quality occurs approximately 4 weeks earlier in prematurely-born infants than in full-term infants. Sleep ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1999
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.146.5.1005